CURRICULUM VITA 

     Adam Antebi

CONTACT INFORMATION

Huffington Center on Aging and 

Department of Molecular and Cellular Biology

Baylor College of Medicine

One Baylor Plaza

Room M-320, N803.02

Houston TX 77030

Phone: 713-798-6661 (office); 713-798-2117 (lab)

Fax: 713-798-4161

Email: aantebi@bcm.edu

EDUCATION

1985-91 Massachusetts Institute of Technology, Department of Biology, Cambridge , MA , Ph.D.

1979-83 Swarthmore College , Swarthmore , PA , B.A with distinction in Biochemistry

RESEARCH EXPERIENCE

2004-present, Assistant Professor, Huffington Center on Aging and Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

1997-2004, Leader of Independent Group, Otto-Warburg Laboratories, Max-Planck-Institut für molekulare Genetik, Berlin, Germany

1992-1997, Post-doctoral fellow, Dr. Edward M. Hedgecock, advisor, Johns Hopkins University , Baltimore , MD

1985-1991, Ph.D. student, Dr. Gerald Fink, advisor. Whitehead Institute of Biomedical Research, Massachusetts Institute of Technology, Cambridge , MA

1983, Undergraduate research, Dr. Robert Pasternack, advisor. Swarthmore College , Swarthmore , PA

1982, Undergraduate research, Dr. Martin Weigert, advisor. Fox Chase Institute of Cancer Research, Fox Chase , PA

FELLOWSHIPS, GRANTS, AWARDS

2006-2011 NIH RO1 A  lipophilic hormone pathway regulating development and aging

2006-2010 NIH RO1 An E3 ubiquitin ligase complex that regulates C. elegans developmental timing

2005-07 Glenn/American Federation of Aging Research Breakthroughs in Gerontology Award

2005-07 NIH Nuclear receptor signaling atlas (NURSA) pilot and feasibility grant

2005-06 Baylor Seed Fund

2004-06 Recipient of National Genome Research Grant on Aging , Germany

2000-03 Recipient European Community Grant, Agegen

1995-97 National Institutes of Health Postdoctoral Training Grant

1992-95 Damon-Runyon-Walter-Winchell Cancer Research Fund Post-doctoral Fellowship

1982-83/1985-87 Beinecke Undergraduate/ Pre-Doctoral Scholar

1983 Sigma Xi and Phi Beta Kappa

1981-82 Babette Spiegel Scholar, Swarthmore College , Swarthmore , PA

1980-81 Anthony Beekman Poole Scholar, Swarthmore College , Swarthmore , PA  

MEMBERSHIPS

2006 The Endocrine Society member

2005 Genetics Society of America member

1998-present AAAS member

2002-05 Science Aging Knowledge Environment (SAGE-KE), participant

2000-01 German Genetics Society, member

PUBLICATIONS  

1. Rottiers, V. and A. Antebi, Control of C. elegans life history by nuclear receptor signaling, Exp Gerontology (in press).

2. Rottiers, V., Motola, D., Cummins. C.L, Gerisch,B., Nishiwaki, K., Mangelsdorf, D. and A. Antebi (2006) Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase, Dev Cell 10, 473-82. (featured in Cell Minireview 124, 1137-40).

3. Motola, D. Cummins,C.L., Rottiers, V., Sharma, K., Sunino, K. ,Xu, E., Auchus, R., Antebi, A. and D.  Mangelsdorf (2006) Identification of hormonal ligands for DAF-12 that govern dauer formation and reproduction in C. elegans Cell, 124, 1209-23 (featured in Cell Minireview 124, 1137-40).

4. A. Antebi (2006) C. elegans  as a model organism for functional genomics, in Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer-Verlag, Heidelberg . Ed. D. Ganton and K. Ruckpaul.

5. A. Antebi (2005) The tick-tock of aging, Science 310, 1911-13.

6.  A. Antebi (2005) “Nuclear hormone receptors in C. elegans” in Wormbook, an online resource for C. elegans . http://www.wormbook.org/  Ed. M. Chalfie, L. Girard.

7. A. Antebi, (2005) The prepared mind of the worm, Cell Metabolism 1, 157-158.

8. Nimmo, R., Antebi, A. and A. Woollard (2005) mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage. Development 132, 5043-54.

9. Shostak, Y., Van Gilst, M.R., Antebi, A., and K. R. Yamamoto (2004)  Identification of DAF-12 binding sites, response elements and target genes.  Genes & Development 18, 2529-44.

10. Ludewig, A., Kober-Eisermann, C., Weitzel, C., Neubert, K., Bethke, A., Gerisch, G., Hutter, H. and A. Antebi (2004), A novel coregulator/nuclear receptor complex controls C. elegans larval development, fat metabolism and aging. Genes & Development 18, 2120-33.

11. Gerisch, B. and A. Antebi.(2004) Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues. Development 131,1765-76.

12. A. Antebi (2004). Inside insulin signaling, communication is key to long life. Sci. Aging Knowl. Environ. Vol. 2004, 23,  pe25

13. A. Antebi (2004). Tipping the balance towards longevity. Developmental Cell 6, 315-16.

14. A. Antebi (2004). Long life: A matter of taste (and smell). Neuron 41, 1-3.

15. Tatar, M., Bartke, A., and A. Antebi (2003), Endocrine Regulation of Aging by Insulin-like signals. Science 299, 1346-51.

16. Gerisch, B. Weitzel, C., Kober-Eisermann, C., Rottiers, V. and A. Antebi (2001) A hormonal signaling pathway influencing C. elegans metabolism, reproductive development and life span, Dev. Cell 1, 841-851 (featured article on Science SAGE/ke website, News Focus Dec. 12, 2001).

17. Antebi, A., Yeh, W.H., Tait, D., Hedgecock, E.M.  and D. Riddle¹ (2000) daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes & Dev 14, 1512-27.

18. Antebi, A., Culotti, J.G., and E.M. Hedgecock (1998) daf-12 regulates developmental age and the dauer alternative in C. elegans. Development 125, 1191-1205.

19. Antebi, A., Norris, C., Hedgecock, E.M. ², and G. Garriga (1997) "Cell and Growth Cone Migrations," in The Nematode C. elegans II, Cold Spring Harbor Press, Ed. D. Riddle, B. Meyer, J. Priess, and T. Blumenthal.

20. Antebi, A. and G.R. Fink (1994) "PMR1" in Guidebook to  Secretory Pathways, Oxford University Press. Ed. J. Rothblatt, T. Stevens, P. Novick.

21. Antebi, A. and G.R. Fink (1992) The Yeast Ca2+-ATPase Homologue, PMR1, is Required for Normal Golgi Function and Localizes in a Novel Golgi-like Distribution. Mol. Biol. Cell 3, 633-54.

22. Rudolph, H.K., Antebi, A., Fink, G.R. , and Buckley, C.M., Dorman, T.E., LeVitre, J., Davidow, L., Mao, J., and D.T. Moir (1989). The Yeast Secretory Pathway Is Perturbed by Mutations in PMR1, a Member of a Ca2+ ATPase Family. Cell 58, 133-45.

23. Pasternack, R.F. , Gibbs, E.J., Gaudemer, A., Antebi, A., Bassner, S., De Poy, L., Turner, D.H., Williams, A., Laplace, F., Lansard, M.H., Merienne, C., and M. Perree-Fauvet (1985). Molecular Complexes of Nucleosides and Nucleotides with a Monomeric  Cationic Porphyrin and Some of Its Metal Derivatives.  J. Amer. Chem. Soc. 107, 8179-86.

24. Pasternack, R.F. , Antebi, A., Ehrlich, B., Sidney , D., Gibbs, E.J., Bassner, S.L., and L.M. DePoy (1984) Interactions of Porphyrins with Nucleotides and Nucleic Acids. J. Mol. Cat. 23, 235.

TEACHING EXPERIENCE AND SCIENTIFIC ACTIVITIES

2006-07 Standing Exam Committee, Molecular and Cellular Biology (MCB), BCM

8/2006 Instructor, MCB Seminar, BCM

4/2006 Instructor, Topics in Development, BCM

3/2006 Coordinator, Biology of Aging and Age-related Disease Course, BCM

2/2006-present Joint Editor-in-Chief, Aging Cell

10/2005 Instructor, Cellular and Molecular Biology Directors Course, BCM

9/2005 NSF grant reviewer

9/2005 Section Editor, Aging Cell

8/2005 NIH ad-hoc study section reviewer, Development and Aging

6/2005 Organizer of International Worm Meeting, Los Angeles .

6/2005 Instructor for NIA course on aging, Ann Arbor

5/2005-6 American Federation for Aging Research study section reviewer

4/2004-06 Lecturer, Biology of Aging Course, Baylor College of Medicine , Houston

11/2003 Advisory Guest, Max-Planck Commision on Gerontology

2002-07 Scientific Advisory Board, Wellcome Trust Grant on Functional Genomics of Aging

5/2003 C. elegans practical course, Freie Universität , Berlin

5/2003 Featured scientist on Max Planck Forum on Aging, Deutsch Welle TV

5/2000-present, initiated Max Planck seminar series and chair of seminar committee

2/2002-present, served on Max Planck election committee

7/2002 Invited lecturer, Universität Göttingen, Göttingen

6/2002 Night of the Scientists: an open house presentation of my laboratory to the public

4/2002 Invited lecturer, Dept. of Biochemistry and Ecotoxicology, Freie Universität , Berlin

2/2002 Featured scientist on Swedish National Radio

2/2002 Invited lecturer, Dept. of Parasitology, Humboldt-Universität , Berlin

1-2/2002 Served on steering committee for Institute Day of Scientific Exchange

4/2000 Featured scientist in television production on aging, channel ZDF

9/1998 Invited lecturer, University of Ghent , Ghent

1997-98 Consultant, Devgen Corporation

1986, Massachusetts Institute of Technology , Cambridge , MA . Teaching assistant for Graduate Genetics (Dr. Gerald Fink, Dr. David Botstein, professors).

1986, Massachusetts Institute of Technology , Cambridge , MA . Teaching assistant for Introductory Biology (Dr. Vernon Ingram, professor).

INVITED TALKS AT MEETINGS and SYMPOSIA

5/2006 European Calcified Tissue Society Meeting, Prague

5/2006 Workshop on Nuclear Receptors and Aging, NIA/NURSA, Potomac

6/2005 Endocrine Society, San Diego

4/2005 Biology of Aging Workshop, Barshop Institute and Nathan Shock Center , Roundtop

5/2004 Nathan Shock Symposium, Model Organisms in the Study of Aging, U. Michigan , Ann Arbor

6/2003 Jacques Monod Conference, Form and Function in Development and Disease, La Londe-les-Maures

5/2003 The Biology of Human Aging, Brown University , Providence

3/2003 Gordon Research Conference on Biology of Aging, Ventura

9/2002 Senior Seminar on Aging, Swarthmore College , Swarthmore

9/2002 Buck Symposium on Neuroendocrine Systems and Life Span Determination, Novato

5/2000 European C.elegans Meeting, Blankenberge

3/2000 Keystone Symposium on Nuclear Receptors, Steamboat Springs

7/1998 Japanese Worm Meeting, Kanazawa

6/1998 European Worm Meeting, Cambridge

5/1997 International Worm Meeting, Madison

INVITED SEMINARS

5/2006 Rutgers University , Piscataway

5/2006 Max Planck Institute for Biochemistry, Martinsried

2/2006 Baylor College of Medicine, Biochemistry, Houston

10/2005 U. of Texas Medical School , Houston

9/2004 Rice University , Houston

10/2003 University College , London

10/2003 Freie Univerität , Berlin

7/2003 National Institute on Aging, Baltimore

6/2003 Baylor College of Medicine , Houston

4/2003 Ecole Normale Supérieure, Paris

4/2003 Karolinska Institute, Stockholm

3/2003 U. of Michigan , Ann Arbor

3/2003 Tufts U. , Boston

12/2002 Johns Hopkins University , Baltimore

12/2002 Washington U. , St. Louis

4/2002 Universität Kiel, Kiel

10/2001 Max-Planck-Gesellschaft Meeting, Berlin

2/2001 Intitute of Genetics and Molecular and Cellular Biology, Strasbourg

3/2000 U. of California , Berkeley

2/2000 Max Delbrück Center , Berlin

1/1999 Max Planck Institut für Endocrinology, Hannover

9/1998 University of Ghent , Ghent

7/1998 Yonsei University , Seoul

3/1997 U. of Colorado , Boulder

3/1997 Rutgers U. , Piscataway

2/1997 Karolinska Institute, Stockholm

1/1997 U. of Indiana , Bloomington

10/1996 U. of Michigan , Ann Arbor

9/1996 National Institute on Aging, Baltimore  

3/1996 Netherlands Cancer Institute, Amsterdam